Just as there is no unexplained love or hate in this world, there is no such thing as inexplicable chest pain! The reason why they feel inexplicable is that they just don’t know the exact cause of the disease. It is important to know that chest pain is a common and life-threatening condition. The causes of chest pain are complex and varied, including acute coronary syndrome (ACS), aortic coarctation, pulmonary embolism (PE), pneumothorax, pericarditis, pericardial tamponade and esophageal rupture. Therefore, it is important to pay sufficient attention to chest pain. Generally speaking, the main diseases that tend to cause chest pain are: 1. Cardiovascular system diseases, which are mostly caused by angina pectoris, myocardial infarction and pericarditis. Angina pectoris, myocardial infarction, aortic valve disease and cardiomyopathy cause chest pain due to myocardial ischemia. 2, mediastinal and esophageal lesions, although these lesions are small, but can not be ignored. This is mostly due to acute mediastinitis, mediastinal tumor, mediastinal emphysema, acute esophagitis, esophageal cancer, etc. 3, chest wall lesions, which is the most common kind of chest pain, such as chest wall trauma, bacterial infection, viral infection, tumor caused by part of the skin, muscle, bone and mental lesions. 4.Diaphragmatic lesions, the cause of which can be in the diaphragm itself or caused by abdominal cavity organ crying disease, mostly seen as diaphragmatic pleurisy, subdiaphragmatic abscess, diaphragmatic hernia, hepatitis, liver abscess, liver cancer, etc. 5, lung and pleural lesions, lung and dirty layer pleura is not sensitive to pain perception, pneumonia, tuberculosis, lung abscess, pulmonary infarction, etc., due to lesions involving the wall layer and the onset of chest pain. These above diseases, which involve a wide range, are related to gastroenterology diseases, cardiology diseases, whistling diseases and thoracic surgery diseases; the consultation requires treatment in different departments according to their pain types. Treatment should never be neglected. It is also important to examine the work of its etiology.