Women who are 36 years old and pregnant with their second child are of advanced age and may be at risk for gestational diabetes, gestational hypertension, venous thrombosis and intrahepatic cholestasis during pregnancy. It is recommended to do relevant pre-pregnancy examinations during the preparation period, such as blood routine, liver and kidney function, coagulation function, thyroid function, regular testing of blood pressure and blood glucose, and prepare for pregnancy without obvious abnormalities in the indicators to reduce the incidence of diseases during pregnancy. 1, gestational diabetes: during pregnancy, the demand for glucose increases, insulin resistance also increases, there will be a relative lack of insulin secretion, and the possibility of gestational diabetes is greater in women of advanced age; 2, gestational hypertension: advanced age is a high-risk factor for the occurrence of gestational hypertension, and in severe cases, there may be complications of pre-eclampsia at the time of delivery, which can pose a threat to mother and child; 3, venous thrombosis: During pregnancy, 36-year-old women’s blood is prone to be in a hypercoagulable state and blood flow is slower, which may lead to deep vein thrombosis of the lower limbs; 4, intrahepatic cholestasis during pregnancy: Due to the elevated level of estrogen in pregnant women, it can lead to cholestasis in the body and symptoms such as skin itching, jaundice, epigastric discomfort, nausea, vomiting and lack of appetite. After liver-protective treatment, the symptoms may improve after delivery, but may recur in another pregnancy; 5. Miscarriage, fetal abortion and preterm delivery: Advanced age is often accompanied by aging of oocytes, and the quality of eggs decreases, making it easy to form abnormal embryos. Therefore, people of advanced age are prone to miscarriage, embryonic abortion and preterm birth; 6. Uterine rupture and vaginal hemorrhage: If a woman’s first child is delivered by cesarean section, there is a scar on the lower part of the uterus, and when the embryo grows on that scar, it will easily cause uterine scar pregnancy, rupture and hemorrhage.