Penile sclerosis in men can be treated by applying medications such as collagenase, hexestrol, potassium iodide, and hydrocortisone acetate. Sclerodactyly, a fibrotic lesion of the cavernous leukomalacia of the penis, causes a single or several plaques or hard nodules to appear on the dorsal or lateral side of the penis. Those with mild symptoms can be treated by local injection of drugs such as collagenase or verapamil, which may have some effect, or by applying vitamins, hexestrol, potassium iodide, etc. as an adjunctive means of treatment. In addition to the above therapeutic drugs, anti-fibrotic drugs such as potassium aminobenzoate can also be applied; early lesions can also try to use hydrocortisone acetate, dexamethasone, procaine and other drugs. The above medicines are for reference only, and specific dosage and usage should follow medical advice. When penile sclerosis occurs, it is recommended to consult a doctor in time, follow the doctor’s instructions for further examination, under the doctor’s comprehensive analysis, choose a reasonable treatment plan, can not blindly take drugs.