When a patient is given an infusion, if uncomfortable symptoms occur, how to identify whether it is an infusion reaction or a symptom caused by the disease itself? Infusion reaction is a general term for adverse reactions caused by infusion, including: pyrogenic reaction, pyrogen-like reaction, allergic reaction, reaction caused by bacterial contamination, phlebitis. Among them, pyrogenic reaction and allergic reaction are more common, but they are not easy to identify, and the treatment program is also different: 1, pyrogenic reaction or allergic reaction? Both pyrogenic reaction and allergic reaction have precursor manifestations such as pallor, chest tightness and nausea when they first occur. In pyrogenic reactions, chills and shivering are more prominent, and after about 10-15 minutes, they can turn into flushing, and after the shivering, or at the same time, high or ultra-high fever occurs. Clinical development is measured in minutes and is relatively smooth compared to the latter. The essence of anaphylaxis is rapid-onset anaphylactic shock, the symptoms of which appear seconds or tens of seconds after the onset of the prodromal symptoms: pale gray face, nausea and vomiting, cold sweat, paralysis, shallow respiration, rapid pulse, a sense of death, fainting, or even cardiac and respiratory arrest, shock and other symptoms. It is a sudden onset of the disease process, the clinical course of which is measured in seconds, and is much more acute compared to the former, without the process of chills and high fever. The treatment program of the two is also different, pyrogenic reaction is based on symptomatic supportive treatment, while allergic reaction is based on anti-allergic, if necessary, need to rescue treatment. The main points of identification of drug allergic reactions and pyrogenic reactions are listed in the table below: 2. Infusion reaction or the disease itself? Speed of occurrence: The progress of the disease itself is generally more gradual, with a time course of 10 minutes, and seldom occurs suddenly. Infusion reactions, on the other hand, occur relatively quickly, with a time course measured in minutes. Symptoms and signs: Chills and fever occurring in the course of the disease itself are usually preceded by chills or other severe symptoms associated with the infection (e.g., severe abdominal pain in intestinal infections). The chills and fever caused by infusion reactions are more intense than the disease itself. However, it cannot be ruled out that some serious infections may also have severe chills and a very high fever. If the patient does not have chills or high fever before the infusion, but develops them within the first 15 to 30 minutes of the infusion, the diagnosis of infusion reaction is likely to be made. Further identification of a pyrogenic or anaphylactic reaction is needed at this time.