Most HIV-infected or AIDS patients can experience skin and mucosal damage during the course of the disease, including infectious skin damage, non-infectious skin damage, and skin tumors: 1. However, they are usually polymorphic and more severe. 2, infectious skin damage manifested as a variety of pathogenic microbial infections, but the disease is more serious than the average patient. (1) Herpes zoster The lesions are often not limited to one, in addition to dense blisters, blisters, blood blisters often appear, pain is intense, very easy to secondary bacterial infection infection, can cause encephalitis, pneumonia, and even death. (2) Herpes simplex (including genital herpes) has frequent recurrences. The distribution of the lesions is limited or disseminated, showing persistent oral, genital, perianal heavy herpes, can not heal for a long time and form deep ulcers. (3) Warts, flat warts, infectious molluscum contagiosum, and condyloma acuminata are frequent, increase rapidly, and occur in areas not normally seen. (4) Fungal infections thrush is the earliest symptom of immunodeficiency, superficial fungal infections (such as generalized ringworm, ringworm and ringworm of the nail) often have more severe lesions; 10% to 13% of AIDS patients can develop cryptococcal infections, often manifesting as herpes-like lesions, the central nervous system is susceptible to involvement and the mortality rate is as high as 38%; coccidioides and paracoccidioides infections are also common. (5) Bacterial or arthropod infections manifest as folliculitis, multiple skin abscesses or boils. Skin tumors: (1) Kaposi sarcoma (KS) is a characteristic cutaneous manifestation of AIDS patients and may be associated with human herpesvirus type 8 (HHV8) infection. Unlike classic Kaposi’s sarcoma, AIDS-associated Kaposi’s sarcoma has smaller and widely distributed damage, with oral lesions common, and neck, trunk, and upper extremities more common, but lower extremities are less frequently involved. (2) Other malignant skin tumors Such as lymphoma, squamous cell carcinoma, basal cell carcinoma, malignant melanoma and Sezary-like syndrome can be seen.