The burning sensation on the soles of the feet in diabetes mellitus is considered to be related to high blood sugar and peripheral neuropathy, which can be alleviated and treated by lowering blood sugar and nutritive nerves. 1. General treatment: diabetic patients with burning sensation on the soles of the feet, it is recommended that first of all, blood sugar should be controlled, avoid eating sweets in daily life, appropriate exercise, in the process of recovery, you can use warm water to soak your feet, thus promoting blood circulation in the feet, to a certain extent, to improve the repair ability of the feet. 2. Drug therapy: first of all, do sugar-lowering treatment, use glimepiride, metformin hydrochloride, acarbose, insulin and other drugs under the guidance of the doctor, and if necessary, you can use nutritive neurotoxic drugs, such as coenzyme A, methylcobalamin, etc., which can to a certain extent alleviate the patient’s uncomfortable symptoms. It is recommended that patients should go to the hospital regularly for rehabilitation checkups and closely monitor their own blood glucose, if they find discomfort, they should also go to the hospital in time for consultation.