Stage 5 diabetic nephropathy may show elevated blood creatinine and urea. The main clinical symptoms are nausea and vomiting, loss of appetite, edema, oliguria, chest tightness, fatigue and so on. Diabetic nephropathy is divided into stages 1~5, stage 5 that is the beginning of blood creatinine elevation, mainly due to the reduction of glomerular filtration rate, can be manifested as nausea, vomiting, loss of appetite and other digestive symptoms, which is the reason for many patients to visit the clinic. Diabetic nephropathy will have a large amount of urinary protein, resulting in severe hypoproteinemia, which will lead to edema, oliguria, and in severe cases, it will even cause chest tightness, shortness of breath, inability to lie down, and other manifestations of heart failure. In addition to this, there can be anemia, electrolyte disorders, acid-base imbalance, such as fatigue and mental weakness. Not all diabetic nephropathy stage 5 have the above manifestations, the diagnosis depends on clinical manifestations and related laboratory tests, especially renal function tests. It is recommended that patients with diabetic nephropathy should consult a regular hospital in time, complete the relevant examinations according to the doctor’s instructions, and give symptomatic treatment.