The average erythrocyte hemoglobin volume, which is the average amount of hemoglobin contained in each red blood cell, has a normal range of 27-34 PG; more than 34 PG is a high average erythrocyte hemoglobin volume. In clinical practice, the most common cause of high mean erythrocyte hemoglobin is megaloblastic anemia. Megaloblastic anemia is associated with folic acid and vitamin B12 deficiency. When folic acid and vitamin B12 are deficient, the nucleus of human red blood cells cannot proliferate and divide normally, resulting in a significant increase in the size of the nucleus, which causes a significant increase in the size of red blood cells, but the synthesis of hemoglobin is not affected, and the amount of hemoglobin contained in the cytoplasm of red blood cells is abnormally high, which eventually causes a significant increase in the average red blood cell hemoglobin. When folic acid and vitamin B12 are administered, the red blood cell volume gradually decreases and the high average hemoglobin volume improves significantly.
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