The academic opinion on vaccination of children with nephrotic syndrome is not yet unanimous. This is because of the dilemma: on the one hand, vaccination may cause recurrence or aggravation of nephropathy (especially in children with pathologically diagnosed microscopic lesions); on the other hand, children with nephropathy who forgo or excessively delay vaccination are at increased risk of developing certain serious (or even fatal) infectious diseases that could have been effectively prevented by vaccination! Our current practice is to: 1) consider vaccination six months after remission (or “recovery”) of nephrotic syndrome; 2) avoid vaccination when higher doses of hormones and/or immunosuppressive drugs are applied; 3) avoid live vaccines (e.g., BCG, measles, and polio vaccines). Vaccines that have just been released (application experience is still insufficient) are also best avoided. It should be noted that after the nephrotic syndrome is cured (or after stopping the use of hormones for more than one year), it is possible to participate in vaccination according to the normal procedure, but like normal children, there may be some side effects such as fever and diarrhea, which should be treated as usual. At the same time, there may be a risk of inducing a recurrence of kidney disease.