Patient: Description of disease (onset time, main symptoms, hospitalization, etc.): The disease started in April 2003 and has been in the Children’s Hospital since then, due to inflammation of the throat caused by the disease. Once got better and cut off the medicine for three months, but in the fall of 2005 due to rhinitis caused the recurrence of renal syndrome, the past few years have been on and off. At the onset of the disease, there is protein in the urine, and when the number of + increases, there are symptoms of swelling. I was on prednisone acetate, then switched to Eugene tablets. Now switched back to Prednisone Acetate 9 tablets a day in the morning. I have always taken medication. When there is inflammation, I add anti-inflammatory and detoxifying medicines, and when the inflammation gets better, the urinary protein will turn negative in two or three days. I would like to ask if I need to have a nephrectomy for such a recurring condition. Is it possible to identify the cause of the disease after renal puncture? Is renal puncture surgery a minimally invasive surgery? How to adjust the condition after the procedure? If I don’t want to have the kidney puncture surgery, is there any other better diagnosis and treatment method. I am worried that my child will not be able to cooperate with the surgery because he is afraid of the surgery. Zhou Taiguang, Department of Pediatrics, Affiliated Hospital of Luzhou Medical College: Repeated episodes of nephrotic syndrome indicate that hormone therapy is ineffective (may be dependent or resistant), and it is necessary to do a renal puncture. Its purpose is not to identify the cause of the disease, but to understand the type of pathology, so as to help determine the further addition of immunosuppressive therapy program. Renal puncture is an invasive test, but it is not very damaging. Your child is over 7 years old and should be able to tolerate it.