Stage 4 diabetic nephropathy needs to pay attention to change the dietary structure, lifestyle, active drug treatment, and renal replacement therapy if necessary. 1. Change the diet structure: patients with diabetic nephropathy stage 4 should have low salt, low fat, high quality and low protein diet, eat milk, eggs and other foods in moderation, and avoid eating foods with high sugar content, such as cakes, drinks and so on. 2. Lifestyle: In daily life, patients should avoid sitting for a long time, need to do proper exercise to keep their weight within the normal range, quit smoking and drinking, and avoid anxiety and nervousness. 3. Drug therapy: actively control the blood sugar level, such as the application of insulin, etc.; control blood pressure, can be applied to ACEI or ARB drugs such as captopril, irbesartan, etc.; correct lipid metabolism disorders, such as the application of atorvastatin, fenofibrate, etc., the need to prevent and delay complications. 4. Renal replacement therapy: When patients with diabetic nephropathy are close to end-stage failure, renal replacement therapy, such as hemodialysis and peritoneal dialysis, is feasible. Patients with diabetic nephropathy stage 4 are advised to go to regular hospitals in time and receive standardized treatment under the guidance of doctors.