Anticoagulation therapy for women of childbearing age after valve replacement surgery is usually not significantly different from that of male patients, but it is different in some special cases. 1, about menstruation: preoperative menstruation is normal women, after valve replacement surgery oral anticoagulant, most of the patients’ menstrual period and menstrual flow some changes, menstrual period is basically similar to the preoperative period, menstrual flow can be slightly increased compared with the preoperative period, the amount of anticoagulant remains unchanged. For patients with regular functional uterine bleeding before surgery, the menstrual period can be prolonged and the menstrual flow can be increased in postoperative anticoagulation, but the cycle is basically unchanged, and the dosage of warfarin can be appropriately reduced under the guidance of the doctor; for example, if there is a lot of bleeding, dysfunctional menstruation, and persistent bleeding, it may be necessary to make other further treatments. 2.About contraception: marriage and sexual life are not hindered after surgery, but it is suggested that 1 to 2 years after surgery, the heart function is fully recovered as well. Female patients should be contraceptive after marriage, the method can take oral contraceptives, or the application of contraceptive devices, or male sterilization, but should not choose the contraceptive ring, so as not to become a chronic inflammatory lesions. Patients taking oral contraceptives should pay attention to check the PT value and adjust the dosage in time to ensure safety. 3, on the issue of pregnancy: with the increase in the number of cases of women of childbearing age valve replacement surgery, the issue of pregnancy has gradually attracted people’s attention. In the past, it was believed that women of childbearing age after valve replacement surgery are not suitable for pregnancy, the reason is that pregnancy is a risk factor imposed on the mother and fetus, in addition to cardiac function status, the main reason is that coumarin anticoagulants have teratogenicity, increased intrauterine bleeding and fetal death risk, data show that (1) more than 40% of pregnancies with miscarriage, preterm delivery, stillbirth; (2) ≥ 5% of the fetus is malformed. Mothers may suffer from thromboembolism due to possible bleeding or hypercoagulability of blood after pregnancy. In recent years, due to the improvement of prosthetic valves, advances in surgical techniques, continuous improvement of anticoagulation, strict control of indications, and close monitoring during pregnancy, the incidence of complications in mothers and infants has been significantly reduced. Therefore, it is best to avoid pregnancy and childbearing in women after valve replacement, but if a woman desires to have children, she may become pregnant only after at least 1 year (generally 2-3 years) after valve replacement, when hemodynamics and cardiac function have improved significantly, and her general condition is good, and she can be guided and monitored by a specialist physician. During pregnancy, PT should be checked regularly and the dosage should be adjusted appropriately to minimize the incidence of maternal and fetal risk. Warfarin can enter the placenta, and there is a risk of fetal malformation when taken in the first trimester of pregnancy. In order to minimize the teratogenic effects of warfarin, it has been suggested that anticoagulation with heparin be used in the first trimester (first 3 months) and at the end of the third to fourth week of pregnancy. We recommend frequent contact with a specialist in obstetrics and gynecology for treatment and guidance during pregnancy. 4, on the issue of interruption of pregnancy: for cardiac function class III-IV is not suitable for pregnancy, the specific circumstances should be consulted with the doctor to obtain health care guidance. For women who are not suitable for pregnancy, if they are already pregnant, it is better to terminate the pregnancy within the first 3 months. Interruption of pregnancy at this stage is easier and less damaging to the patient. Medications should be used under the guidance of a specialist. 5, on the issue of delivery: generally 1 to 3 weeks before the expected date of delivery hospitalized waiting for delivery. If there is no special, some of them can be successfully delivered vaginally. If the cardiac function is above grade II and there are fetal and obstetric indications, cesarean section is feasible. To reduce labor hemorrhage and prevent embolism, Warfarin can be stopped 3 days before the expected date of delivery and switched to intravenous short-acting anticoagulant heparin 0.5 mg/kg/4 hours, and heparin can be discontinued 12 hours before surgery. In case of spontaneous delivery, heparin was discontinued at the beginning of labor, and PT and APTT were checked to be close to normal control levels for elective cesarean section or spontaneous delivery. Vit k 10mg was injected intravenously through the umbilical cord after the birth of the infant, and the mother resumed anticoagulation therapy by starting sedated heparin after delivery if there was no bleeding. After 48 hours of delivery, oral warfarin anticoagulation was changed to be used, and PT and APTT were detected in a timely manner, because breast milk contains anticoagulants, it is not advisable to breastfeed the baby. In addition, the blood coagulability of pregnant and breastfeeding women has greater changes, and some patients need to increase the dose of anticoagulants. Therefore, these patients should pay attention to review.