Four years ago, she had three consecutive ectopic pregnancies in just eighteen months, one left tubal pregnancy, two right tubal pregnancies, three consecutive surgical treatments, was painful and helpless, coupled with the hopelessness of natural reproduction, the couple agreed to avoid another ectopic pregnancy, the implementation of strict contraception, do not dare to think about the issue of reproduction. Until one day, they heard about “in vitro fertilization”. After consultation, they rekindled the hope of having a child, and in vitro fertilization-embryo transfer technology would be the only “lifesaving straw” for them to have a child. The development of science and technology often brings us more hope and miracles, today let’s talk about repeated ectopic pregnancy. What is ectopic pregnancy? Under normal circumstances, the ovary expels the mature egg, and the egg and the sperm, which have already arrived, meet in the fallopian tube and combine to form a fertilized egg. There is a layer of very fine “cilia” in the fallopian tube, and the fertilized egg moves towards the uterus with the swinging of the “cilia” while splitting in the fallopian tube, and reaches the uterine cavity after about 3~4 days, and the fertilized egg is successfully implanted in the lining of the uterine body cavity. In abnormal cases, when the fertilized egg is deposited in a place other than the uterine cavity, it is called ectopic pregnancy, and ectopic pregnancy refers to a pregnancy outside the uterus. The most common site of ectopic pregnancy is the fallopian tube, and tubal pregnancy accounts for more than 95% of ectopic pregnancies, and the site of its occurrence is the most common in the jugular abdominal pregnancy, accounting for about 60%, followed by the isthmus, accounting for about 25%, and the umbrella and interstitial part of the pregnancy is rare. Because the tubal wall is very thin, the tube is relatively thin, not able to adapt to the needs of the growth and development of the fertilized egg, so soon after the pregnancy tubal rupture, causing bleeding, without timely rescue will be life-threatening. Common causes of ectopic pregnancy】 The most common causes of ectopic pregnancy are tubal dysfunction and chronic inflammatory diseases of the pelvis. 1, pelvic tubal inflammation: can be divided into tubal mucositis and tubal peritubal inflammation. Severe tubal mucositis can cause complete obstruction of the lumen and cause infertility, mild tubal mucosal adhesions and cilia defects affecting the operation of the fertilized egg is impeded and implanted in the place. Peritubal inflammation lesions are mainly in the plasma membrane layer or plasma muscle layer of the fallopian tube, often resulting in adhesions around the fallopian tube, tubal distortion, luminal narrowing, wall muscle peristalsis is weakened, affecting the operation of the fertilized egg. Gonorrhea and Chlamydia trachomatis caused by tubalitis often involves the mucosa, and abortion or post-delivery infections often cause peritubal inflammation. 2, tubal surgery history: this is also a common factor, tubal sterilization if the formation of tubal recanalization or fistula, have led to tubal pregnancy may be; or due to infertility had received tubal separation adhesion surgery, tubal plasty, such as tubal anastomosis, tubal opening surgery, etc.; had suffered from tubal pregnancy of women, the recurrence of tubal pregnancy may be large, regardless of whether it is a tubal resection or conservative surgery After the tubal resection or conservative surgery, the incidence of another tubal pregnancy is about 10% to 20%, which is what we call repeated ectopic pregnancy. 3.Tubal dysplasia or abnormal function: Tubal dysplasia is often manifested as long fallopian tube, poor development of muscle layer, lack of mucosal cilia. There are other double fallopian tubes, diverticulum or parasol, etc., all of which can be the cause of tubal pregnancy. Tubal function is regulated by estrogen and progesterone. If the secretion of estrogen and progesterone is abnormal, it can affect the normal operation of the fertilized egg. In addition, mental factors can also cause tubal spasm and peristaltic abnormalities, interfering with the transportation of the fertilized egg. 4, fertilized egg wandering: egg fertilization in one side of the fallopian tube, fertilized egg through the uterine cavity or abdominal cavity into the opposite side of the fallopian tube called fertilized egg wandering. Migration time is too long, the development of the fertilized egg is enlarged, can be in the opposite side of the fallopian tube in the formation of tubal pregnancy. 5, other factors: fallopian tube due to the compression of surrounding tumors such as uterine fibroids or ovarian tumors, especially endometriosis caused by fallopian tubes, ovaries around the tissue of the adhesion, can also affect the tubal lumen, so that the operation of the fertilized egg is blocked. Some studies also believe that defects in the embryo itself, abortion, smoking, etc. are also related to the development of ectopic pregnancy. Common treatment methods of ectopic pregnancy] 1, drug conservative treatment; 2, surgical resection of the affected fallopian tube, i.e. radical surgery, can be by cesarean section or laparoscopic surgery; 3, retain the affected side of the fallopian tube surgery, i.e. conservative surgery, can be by cesarean section or laparoscopic surgery; 4, such as fallopian tube pregnancy, if the person who has given birth to a child, generally use the fallopian tube resection, especially applicable to the emergency patients who suffer from internal hemorrhage complicating shock. [The end of ectopic pregnancy treatment] Because the fallopian tube and ovary are bilateral, therefore, after unilateral tubal pregnancy, it is not absolutely infertile, as long as the other side of the fallopian tube function is normal and undamaged, there is still a chance to get pregnant and have a baby, but of course, there is also the risk of another ectopic pregnancy. According to the survey, there have been ectopic pregnancy in women, 10% -15% will have another ectopic pregnancy, 50% of the people infertile, 35% -40% can have a normal intrauterine pregnancy. Therefore, women who have had an ectopic pregnancy should go to the hospital in time for an early diagnosis of the pregnancy and to rule out another ectopic pregnancy if they become pregnant again. It is best to do an ultrasound examination around 50 days of pregnancy, according to the location of the embryonic sac and fetal cardiovascular pulsation, it can be determined whether it is an intrauterine pregnancy or ectopic pregnancy, in order to eliminate the worries at an early stage. Once irregular vaginal bleeding occurs in the early pregnancy period, you should consult a doctor as early as possible, and strive to make a diagnosis before the severe abdominal pain occurs, i.e. before the tubes are ruptured. How to prevent ectopic pregnancy again? First of all, should be timely treatment of reproductive system diseases, including pelvic tubal inflammation, endometriosis, etc.; Second, reduce abortion and other increased pelvic, uterine cavity lesions of the uterine operation, such as not considering motherhood, we must do a good job of contraception, good contraception can be fundamentally eliminate the occurrence of ectopic pregnancy; Third, for some patients, especially for ectopic pregnancy conservative treatment of ectopic pregnancy after the plan for a second pregnancy of the patient, can observe the ovulation before the ovulation period, the ovulation period, the ovulation period can be observed, the ovulation of the ovulation period can be observed before the ovulation period, the ovulation period can be observed before the ovulation period. You can observe which side of the ovulation is going to happen before the ovulation period, and choose the cycle of ovulation on the side of the ovary that has not suffered from ectopic pregnancy and then choose the period for intercourse. At present, many infertility patients to solve the pelvic adhesions, tubal lesions and other problems implemented laparoscopic surgery to unblock the fallopian tubes, this kind of patients can not judge the recovery of the fallopian tube surgery, the risk of ectopic pregnancy after the surgery is also very high, so after the surgery should be active to prevent inflammation, pregnancy as soon as possible to check to rule out ectopic pregnancy. If ectopic pregnancy is obtained again after laparoscopic surgery, it can be considered that the function of the fallopian tube is abnormal, and it is recommended to consider in-vitro fertilization-embryo transfer for pregnancy (IVF). However, when both fallopian tubes have had ectopic lesions, the chances of another ectopic pregnancy and infertility are high, and the possibility of a natural pregnancy is very low. For those patients who have had one ectopic pregnancy and then another ectopic pregnancy, it is not recommended to blindly expect and repeatedly continue to try to conceive, while patients with more than two recurrent ectopic pregnancies are recommended to use contraception and look forward to IVF technology to help them conceive. In vitro fertilization-embryo transfer technique】 In vitro fertilization-embryo transfer technique is to take out the egg and sperm of the patient and his/her couple outside the body, fertilize them in a petri dish, and transfer them into the patient’s uterine cavity after they have developed into an embryo, so that it can be planted to achieve the purpose of pregnancy, so it is also known as in vitro fertilization. For patients with tubal obstruction, repeated ectopic pregnancies, poor tubal function, or those who still cannot get pregnant naturally even though their tubes have been surgically unblocked, as long as they still have a certain amount of ovarian reserve, they can choose this method to solve their fertility problems. For patients with repeated ectopic pregnancies, IVF is definitely the best way to help them conceive. This is how Ms. Xiao Liang became a happy mother.