The treatment of mid-term diabetic foot mainly includes hypoglycemic treatment, improvement of blood circulation, anti-infection and surgical treatment, etc. The specific treatment should be based on individual situation. 1. Glucose-lowering treatment: first of all, blood sugar should be controlled, patients can take metformin, acarbose, glimepiride and other drugs for treatment, and if necessary, insulin can be injected for treatment, so as to control the blood sugar at the target value. 2. Improve blood circulation: expand blood vessel, anticoagulation, dissolve thrombus, make large blood vessel and microcirculation dredge again, so as to make the blood flow of limb end unobstructed, and the local blood supply of gangrene is well improved. 3. Anti-infection: use effective antibiotics to control systemic or local infection of gangrene, reduce the local spread of gangrene and the occurrence of sepsis. 4. Cleansing treatment: remove the necrotic tissues, apply foreign drugs on the wound surface, promote skin regeneration and prompt the wound to heal as soon as possible. 5. Surgical treatment: including vascular reconstruction, interventional therapy, autologous tissue transplantation, etc. If there is gas gangrene in the middle stage of diabetic foot, gangrene in the anterior part of the foot with ulcers, amputation is feasible. It is recommended that the patient should go to the hospital in time and be treated under the guidance of the doctor.