The vast majority of patients can be controlled by regular medication, and thus medication remains the most important treatment, with the principle of single and long-term use. When a drug does not work well and needs to be replaced with another drug, it is important not to change the drug suddenly. It is necessary to gradually increase the new drug to the effective dose and then gradually reduce the dose of the original drug, and at the same time, to consider whether there is an interaction between drugs and adjust the new drug dose, which should be done under the guidance of a doctor. In addition, the efficacy of the drug is gradually revealed, and the drug concentration should be confirmed by blood test to be reasonable, and the patient is not satisfied with the efficacy of the drug before considering changing the drug. After the replacement of several drugs are not effective, then consider the combination of drugs, and to regularly review the blood routine and liver and kidney function to reduce the occurrence of side effects.