In chronic osteomyelitis, due to the stimulation of purulent secretions, the surrounding soft tissues will undergo pathological changes, with heavy edema, hardening of the base and skin pigmentation. If it is not cured for a long time, such as several years or more than ten years, it is easy to become cancerous. The main symptoms before carcinoma are: 1. Increased secretion from sinus tract or trauma surface, sometimes with blood, accompanied by corpse odor or foul smell. 2. 2.Traumatic erosion, rapid proliferation of skin edge or jagged change of skin edge without closing phenomenon. 3.Sometimes the granulation tissue of the trauma surface is uneven in height, and the whole trauma surface is crater-like changed and bleeds easily when touched. 4. A large amount of white secretion adheres to the surface of the granulation, which is difficult to remove by clinging to the base and appears as a red and white interval with a cauliflower shape; 5. The pain is unbearable and worsens at night, and general painkillers are not effective. For chronic osteomyelitis sinus tract or trauma that does not heal for a long time, in order to prevent cancer, timely treatment is required until clinical cure.