1, osteomyelitis according to the bacterial culture drug sensitivity test to select antibiotics, to inform the health care provider of the medication history and allergy history. If there is a history of allergy to inform the health care provider in time to facilitate treatment. 2, after negative skin test, the first application of the first half hour 15 ~ 30 drops, the speed should be slow, pay attention to observation, such as panic, skin rash, skin redness in a timely manner according to call, or let the family notification to inform the nurse. 3, after the drip rate nurse adjusted, the patient or family members can not adjust the speed of the liquid themselves. 4.Be alert to secondary infections during the medication process, and inform the doctor promptly if there is oral fever, ulceration, diarrhea and other symptoms occur.