The pathogenesis of premature ejaculation is complex, and many studies over the past two decades have concluded that premature ejaculation may be caused by somatic disorders and neurobiological disorders. Common causes include: glans penis sensitivity, high sensitivity of the pubic nerves, dysregulation of central 5-hydroxytryptaminergic neurotransmission, erectile difficulties, prostatitis, etc. It is worth noting that there are no strong studies to confirm any organic cause. So if it is simply due to glans sensitivity, a dorsal penile nerve block certainly has a very good outcome, but things are often not so pure. There is no evidence that selective dorsal penile neurectomy is effective in the treatment of premature ejaculation, and the surgical procedure has the potential to cause permanent loss of sexual function, and this type of therapy is not currently recommended in the treatment of premature ejaculation.