There are unpredictable winds and clouds in the sky. One day, a young man suddenly felt that the vision of his right eye decreased, there were dark shadows in the center of his vision, and his vision was distorted. He went to the hospital and found macular hemorrhage and exudation, and was diagnosed with idiopathic choroidal neovascularization by OCT and fluorescence angiography, and was recommended to undergo photodynamic therapy (PDT). The fundus includes the retina, choroid, macula, optic nerve and other structures. Once a lesion occurs it can severely affect vision. Neovascular growth is one of the more difficult conditions in ophthalmology. It is commonly seen in retinal vein occlusion, diabetic retinopathy, macular degeneration, high myopia, idiopathic CNV, etc. It will cause hemorrhage, edema, exudation, and involve the macula to cause visual impairment. At present, in addition to controlling the primary pathology, ophthalmology adopts the main treatment methods of laser therapy, such as argon laser, multi-wavelength laser, photodynamic therapy. Particularly serious also need surgical intervention, such as caused by vitreous hemorrhage, vitreoretinal hyperplasia need to be performed glass excision, in the operation or postoperative laser treatment. Fundus neovascularization (CNV) can be controlled and slowed down after treatment, but it cannot be completely removed, so the treatment should be as early as possible, once the lesion has migrated for too long and caused serious damage to the nerve cells, it will be very difficult to restore vision. The treatment should be followed up frequently and may need to be repeated depending on the condition. Advances in technology have brought good news to patients with eye diseases, and photodynamic therapy has saved countless difficult-to-treat eye diseases that were previously out of reach. At present, photodynamic therapy is still only available in a few large hospitals, as it requires specialized technical knowledge and equipment conditions, and can only be implemented after rigorous examination and diagnosis. With the deepening of CNV research, anti-VEGF therapy is showing unlimited application prospects, and I believe it will bring hope and joy to domestic patients in the near future!