Postoperative peroneal vein thrombosis requires appropriate treatment according to the patient’s specific situation. 1. If the patient only has peroneal vein thrombosis, the risk is generally small, and then the patient can have appropriate activities, and anticoagulation therapy is needed. Anticoagulant treatment mostly adopts subcutaneous injection, such as subcutaneous injection of low molecular heparin, and can be combined with oral coagulation factor inhibitors, such as rivaroxaban and so on. 2. If there is venous thrombus in the peroneal vein, or even deeper, such as iliac vein, surgical intervention is needed, such as catheter suction, which can draw out the thrombus or dissolve the thrombus by injecting thrombolytic drugs into the catheter. If the thrombus is relatively large, and if the thrombus is dislodged, which may lead to pulmonary embolism, then filters can be put inside the vena cava to prevent pulmonary embolism from occurring. Postoperative peroneal vein thrombosis needs to be treated according to the patient’s specific situation. When there is thrombus in the postoperative body, it is necessary to timely treatment under the guidance of the doctor, after a clear diagnosis to take targeted treatment, not private treatment, so as not to cause adverse consequences.