In clinical practice, bedridden patients should do the following to better prevent the occurrence of thrombosis: First, bedridden patients cannot get out of bed, so they should massage their limbs from time to time, and the time of each massage should preferably not be less than 30 minutes, and they should turn over and pat their backs from time to time, which can well prevent the occurrence of thrombosis because it can promote the blood circulation of patients. Second, bedridden patients can use anticoagulant drugs appropriately for anticoagulation therapy. Anticoagulant drugs can prevent the formation of deep vein thrombosis or arterial thrombosis, and once the patient is bedridden for a long time, it is recommended to use anticoagulant drugs, and the anticoagulant drugs often used in clinical practice include low molecular heparin sodium, warfarin, rivaroxaban, dabigatran, etc. When using these anticoagulants, it should be noted that patients only need to choose one of them for anticoagulation treatment. These anticoagulants are safe and effective for patients and can well prevent the formation of blood clots.