If a couple has been living together for more than one year without using any contraception, and the woman is unable to conceive due to reasons on the part of the man, it is called infertility. Infertility seriously affects the happiness and harmony of the family. Causes of male infertility mainly include: endocrine sterility, chromosomal abnormalities, only Sertoli cell syndrome, acquired diseases, environmental toxic testicular injury such as: ionizing radiation, smoking, alcoholism, etc.; genitourinary tract infections, such as orchitis, etc.; erectile dysfunction, ejaculatory dysfunction; immune infertility and so on. The causes of male infertility are extremely complex and may be influenced by a single factor or multiple factors. In view of the complexity of the causes of infertility, infertile couples correct diagnosis is crucial, then how to infertility patients correct diagnosis? 1, face the reality, correct mindset, establish confidence, early treatment. Infertility patients face the pressure of the family, most are more nervous. Excessive tension will affect the operation of the three major systems of nerves, endocrine and immune system, which in turn affects the quality of sperm and the effect of treatment. Therefore, infertility patients should not be too worried, should establish confidence. 2, do not believe in advertising, choose a regular hospital. It is important to choose a regular hospital. Regular hospitals can ensure that the professional qualifications of doctors, according to the patient’s condition, combined with professional, modern inspection, monitoring means to make a scientific diagnosis, and then determine the best treatment plan. 3, actively cooperate with the doctor treatment. Infertility patients receive drug treatment, the course of treatment should be generally 1~2 spermatogenic cycle, that is, 3~6 months. The course of medication is sufficient, but still can not have children, should consider taking assisted reproductive technology to achieve the purpose of reproduction. Assisted Reproductive Technology (ART) is a revolution in human reproductive technology, which refers to a series of clinical and laboratory techniques for achieving fertility through the processing of sperm, egg or placenta. When choosing a strategy for assisted reproduction, one should follow the “principle of de-escalation”, i.e., an assisted reproduction technique in which the husband’s semen is optimized and injected into the woman’s reproductive tract in a non-coital way, so that the sperm and egg can naturally combine to achieve a pregnancy and birth; and secondly, one should consider the relatively expensive and damaging technique commonly known as IVF, i.e., in vitro fertilization (IVF), which is a method of fertility treatment. Secondly, we will consider the relatively expensive and damaging technique called “In Vitro Fertilization (IVF)”, in which the sperm and eggs of infertile couples are taken out of the body, fertilized in an in vitro culture system and developed into embryos, and then the high-quality embryos are transplanted into the patient’s uterine cavity, or with the help of microsurgical operation system, single sperm are injected into oocyte plasma to fertilize the sperm directly outside the body, and then embryo transfer into the uterus is carried out to achieve a pregnancy.