Common name: Sodium vitamate injection [Ingredients] The main ingredient of this product is sodium vitamate, the excipients contain sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate. Chemical name: (1→4)-O-β-D glucuronide-(1→3)-2-acetylamino-2-deoxy-β-D glucose. Molecular formula: (C14H20NO11Na)n Molecular weight: 1,500,000～2,500,000,000 Sodium vitaminate is a physiologically active substance widely present in human body, a mucopolysaccharide formed by the polymerization of a disaccharide unit consisting of glucuronic acid and acetylaminohexose. Properties】This product is a colorless and clear viscous liquid. Indications】Knee osteoarthritis, frozen shoulder and other diseases. Specification】2ml:20mg 【Dosage and Administration】This product is used to improve osteoarthritis of the knee and frozen shoulder. For osteoarthritis of the knee, inject into the knee joint cavity; for frozen shoulder, inject into the shoulder joint cavity or subacromial bursa. 2ml once, once a week, 5 weeks as a course of treatment. Adverse reactions】Patients may experience pain, rash, itching and other symptoms at the injection site, which can generally disappear on their own within 2-3 days. Contraindications】Unspecified 【Caution】1. 2. Do not contact with drugs containing Jell-O to avoid clouding. 3. In case of joint effusion, the effusion should be extracted first and then injected into the drug. Pregnant women and nursing mothers】Unspecified. For Children】Unclear. For Elderly] Not available. Drug Interaction】Unspecified. Overdose】Unspecified. Pharmacology and Toxicology】Sodium vitrate is the main component of synovial fluid and is one of the components of cartilage matrix. It plays a lubricating role in the joint cavity to reduce friction between tissues, and at the same time plays an elastic role to buffer the stress on the joint cartilage to perform its proper physiological function. The injection of high molecular weight, high concentration and high viscoelasticity of sodium vitrate into the joint cavity can significantly improve the inflammatory reaction of synovial fluid tissue, increase the content of sodium vitrate in synovial fluid, enhance the viscosity and lubricating function of joint fluid, protect joint cartilage, promote the healing and regeneration of joint cartilage, relieve pain and increase joint mobility. Pharmacokinetics】Injected into the joint cavity for 24 hours, the product enters the synovial membrane, cartilage surface and some adjacent muscle tissue and intermuscular space, and the concentration in the synovial fluid, meniscus and cartilage surface reaches its peak. At 72 hours of administration, the residual amount in the joint cavity is about 10% of the drug delivery, and the concentration in plasma reaches its peak at this time, and it is distributed in the liver, spleen and kidney, and the concentration in the above organs can be 2-6 times higher than the plasma concentration. After 9 days of administration, very small amounts of metabolites are excreted in the urine, and most of them are metabolized by respiratory oxidation and carbon dioxide production. The clearance rate of sodium vitrate in the body is the same whether it is given as a single dose or multiple doses. Storage】Store in a closed place under light. Protecting and repairing cartilage Improving joint function Sodium vitrate is a physiologically active substance widely present in human body, which is a mucopolysaccharide formed by the polymerization of a disaccharide unit consisting of glucuronic acid and acetylaminohexose. Five mechanisms to protect and repair cartilage and treat joint diseases 【Protect cartilage and promote repair】 SPECTRO can form a viscoelastic protective film on the surface of cartilage, re-establish the natural barrier that has been destroyed, prevent further destruction and loss of cartilage matrix, and promote the healing and regeneration of joint cartilage. Lubricates joints and reduces friction】 The unique water retention and high viscoelasticity of SPRITE can protect and lubricate joints, reduce friction between tissues and increase joint mobility. Inhibit inflammation and reduce exudation】Sprite has a strong inhibitory effect on the diffusion of inflammatory mediators (barrier effect), reducing the permeability of synovial membrane and intra-articular exudate. Pain relief and improvement of function】Sprite covers and protects nociceptive receptors, inhibits the excitability of synovial and subsynovial nociceptive receptors and nociceptive fibers, rapidly and permanently relieves joint pain and improves joint movement function. Promote HA synthesis, with long-lasting effect】Sprite restores the function of synovial cells to synthesize high molecular weight sodium vitrate, increases the content of sodium vitrate in synovial fluid, and enhances the viscoelasticity and lubricating function of joint fluid.