Patient: Married for two years without pregnancy Semen routine 1: volume 2ml, color grayish white, liquefaction time 30, viscosity medium, PH 7.0 Sperm density: occasional live sperm after centrifugation, remark: Class D visible under the original film. Semen routine 2: volume 2ml, color grayish white, liquefaction time 30, consistency medium, PH value 75, more than 10 D classes were seen under the full view. Prostate examination; Lecithin ++++ WBC++ Sex hormone six 1: FSH : 7.56IU/L LH : 4.70IU/L E2; 29PG//ML PROG : 0.38NG//ML PRL17.69 NG/ML T : 4.75NG/ML Sex hormone six 2: FSH : 8.70IU/L LH : 2.90IU/L E2; 128PMOL/L PROG: 1.27NMOL//L PRL: 4.24 MIU/L T: 18.38NMOL/L Ultrasonography suggested; no abnormalities in both kidneys, ureter, bladder and prostate. Used compound Xuanju, chicken blood vine capsule, prostate capsule, bromocriptine as well as herbal medicine, no improvement in semen on recheck after 3 months. Can such dead sperm still undergo IVF? Where does live sperm come from? Do I need to have an epididymal puncture? What are the chances of achieving live sperm with medication? Thank you! Longjie Gu, Reproductive Medicine Center, Wuhan Tongji Hospital: You can consider IVF treatment (ICSI) and hopefully have your own child. There are precedents of success in this area. It is recommended to visit the reproductive medicine center of a regular hospital that has been approved by the Ministry of Health to carry out IVF technology. The term “dead sperm” does not mean that all the sperm in the semen are dead, but that none of the sperm are motile, in this case there are actually some sperm that are alive, but lack motility. Such sperm can be done with ICSI. The doctor will pick these sperm out and use them when doing IVF. Epididymal puncture is not very helpful in this case. In general, it is best to first test the sperm survival rate to see what percentage of those non-motile sperm are alive. As long as it is not very low, you can prepare for IVF. In addition, it has been observed that many dead spermatozoa can find a small number of sperm with weak motility after in vitro culture, which can be used for ICSI.