Lenvac, commonly known as Lenvatinib, and Cabozantinib usually can not be taken in combination, if there are indications for the drug, then it can be used in combination under the guidance of a doctor. Lenvatinib belongs to the class of methylsulfonate drugs and is mainly used for the treatment of unresectable hepatocellular carcinoma that has not received systemic treatment; cabozantinib can inhibit the activity of related enzymes, thus exerting the effect of anti-tumor, killing tumor cells and reducing the chance of tumor metastasis, and is mainly used for the treatment of progressive, metastatic medullary thyroid carcinoma. Although both drugs can be used in the treatment of malignant tumor diseases, while there is no drug interaction between the two drugs, but their drug indications are different, therefore, usually can not be taken in combination; if there are the above drug indications, then you can be under the guidance of the doctor under the guidance of the combination of medication therapy. Usually after the use of Lenvatinib may appear high blood pressure, proteinuria, cardiac dysfunction and other discomforts, for the drug components of the allergy is prohibited; in the process of using the drug need to monitor the blood pressure, renal function, etc., for pregnant women and breastfeeding women and other special populations, need to be in the doctor or clinical pharmacist under the guidance of the use of medication. Secondly, Cabozantinib may cause sepsis, cardiac arrest, nausea, vomiting and other discomforts, and for moderate and severe hepatic insufficiency, the drug component allergy is prohibited; need to pay attention to the monitoring of liver function in the process of drug use, to avoid liver insufficiency caused by the drug, and for pregnant women, children and other special populations, need to be in the doctor or clinical pharmacist under the guidance of the use of the drug. The above medication should be used under the guidance of a doctor or clinical pharmacist to avoid self-medication, which may lead to adverse reactions.