Peritus ani (PA) is a common localized pruritus. It is sometimes mildly itchy in the anus, but becomes pruritus if the itching is severe and persists over time. It is a common confined neurological dermatosis. It is usually limited to the perianal area, and some may spread to the perineum, vulva or the back of the scrotum. It occurs mostly in middle-aged and older people between 20 and 40 years old. It is more common in men than in women, and this pruritus occurs more often in people who are used to quietness and infrequent exercise. Secondary pruritus has an obvious causative cause and is easily treated; spontaneous or unexplained PA is not easily cured and also often recurs, accounting for about 50% of all patients. Anal pruritus combined with clinical symptoms and signs, it is not difficult to diagnose the disease, but it is more difficult to clarify the cause, generally anal localized with primary and not transformed into secondary general is limited to the perianal area, some can spread to the perineum, vulva or the back of the scrotum. It occurs mostly in middle age and old age from 20 to 40 years old. It is more common in men than in women, and this pruritus occurs more often in people who are used to quiet and infrequent exercise. Secondary pruritus has an obvious causative cause and is easily treated; spontaneous or unexplained PA is not easily cured and also often recurs, accounting for about 50% of all patients. Anal pruritus combined with clinical symptoms and signs, it is not difficult to diagnose this disease, but it is more difficult to clarify the cause, generally there is a local primary and not transformed into secondary pruritus in the anus, otherwise it is primary pruritus. In addition, a general physical examination should be performed, and the necessary laboratory tests should be done in a targeted manner, such as blood, urine, stool routine, liver and kidney function, urine sugar, blood sugar, glucose tolerance test and or tissue and smear tests. 1. Treat primary or comorbid conditions such as hemorrhoids, anal fistula, pinworms, etc. Give appropriate antibiotics or antimicrobials to treat co-infections. 2, avoid inappropriate self-treatment, many anal pruritus patients do not want to go to the hospital, take improper self-treatment, such as scalding with hot water, external use of high concentrations of corticosteroids, etc., these methods do more harm than good, only a temporary suppression of itching, over time, resulting in the lesions move to increase, patients should be advised to stop using. 3, pay attention to hygiene, do not eat irritating food, such as spicy food, strong tea, coffee. Clothing should be loose fitting, close underwear to cotton fabric is good. 4, limited anal pruritus drug treatment should be based on local topical drugs, systemic treatment of various preparations of drugs, without clear indications should be avoided. Pruritus, otherwise primary pruritus. In addition, a systemic physical examination should be performed, targeted to do the necessary laboratory tests, such as blood, urine, stool routine, liver and kidney function, urine sugar, blood glucose, glucose tolerance test and or tissue and smear and other tests. 1. Treat primary or comorbid conditions such as hemorrhoids, anal fistula, pinworms, etc. Give appropriate antibiotics or antimicrobials to treat co-infections. 2, avoid inappropriate self-treatment, many anal pruritus patients do not want to go to the hospital, take improper self-treatment, such as scalding with hot water, external use of high concentrations of corticosteroids, etc., these methods do more harm than good, only a temporary suppression of itching, over time, resulting in the lesions move to increase, patients should be advised to stop using. 3, pay attention to hygiene, do not eat irritating food, such as spicy food, strong tea, coffee. Clothing should be loose fitting, close underwear to cotton fabric is good. 4, limited anal itching drug treatment should be based on local topical drugs, systemic treatment of various preparations of drugs, without clear indications should be avoided. Severe and prolonged anal pruritus should go to a regular hospital, if necessary, injection therapy or surgical therapy.