There are many reasons why a girl’s anus is particularly itchy in the folds. First of all, we should consider whether there are clothes that are too snug and not breathable, poor anal hygiene, consumption of spicy and stimulating foods, allergies, etc. In this case, we should change underwear regularly, wash and expose underwear correctly, keep the perianal area clean and dry, eat lightly, and stay away from allergens to relieve the symptoms, most of which will disappear after a few days. Secondly, there may be a bacterial infection in the anus, or it may be caused by fungal or parasitic infections, or hemorrhoids. The girl should first go to the hospital to clarify the cause, and then for the cause of targeted treatment. 1, bacterial infection: girls anal bacterial infection may be related to long-term diarrhea resulting in repeated stimulation of perianal skin, generally patients feel perianal redness, burning, itching discomfort, skin rash may appear and other symptoms, need to be under the guidance of the doctor to apply local anti-itch cream, take antibiotics and other anti-inflammatory drugs, commonly used Drugs include erythromycin ointment, levofloxacin hydrochloride ointment, metronidazole, tinidazole, etc. You can also take a sitz bath with antiseptic and anti-inflammatory medication after stool, such as potassium permanganate solution, which can be used as prescribed by your doctor to relieve itching. If there is an anal fistula, it may be necessary to surgically remove the fistula, and local hygienic care is needed after surgery to avoid secondary infection; 2. Fungal infection: it may be related to cross-infection in other parts of the body, typically manifested by a rash or blisters on the skin of girls. Anal pain, incomplete defecation, constipation, blood in the stool, and even anal incontinence may occur. At this time, antifungal medication, such as fluconazole cream and terbinafine butylate ointment, should be applied under the guidance of a doctor. Such patients must seek medical attention for pathogenic bacteria laboratory tests, if the abuse of antibacterial drugs, not only detrimental to the control of the disease, but also may aggravate the disease; 3, parasitic infection: girls can feel the sensation of worms crawling around the anus bite, generally more common at night, it is recommended that patients under the guidance of doctors oral dispel worm drugs, such as mebendazole, thiabendazole, etc., and combined with antibacterial anti-inflammatory drugs. Daily attention to dietary hygiene, because most intestinal parasitic infections are caused by unclean diet, and wash your hands before eating; 4, hemorrhoids: when hemorrhoids repeatedly prolapse, the viscous secretions of hemorrhoids will continue to stimulate the skin around the girls’ anus, which may trigger chronic inflammation around the anus, resulting in itching discomfort around the anus. At this point it is recommended to have a medical examination to clarify the type and extent of the lesion and to treat it symptomatically under the guidance of a doctor. Usually you can use hemorrhoid creams, hemorrhoid suppositories to relieve, also can assist warm salt water sitz bath to relieve, if the condition is serious, need to surgically remove the hemorrhoid nucleus. The hemorrhoids are mostly caused by long-term increased abdominal pressure, so daily avoid situations that can cause increased abdominal pressure, such as sedentary, too long toilet time, etc.; 5, anal pruritus: the cause is more complex, in addition to itching, can also be accompanied by burning, pain and other symptoms, can affect the girls’ daily life and night sleep. You can take anti-allergy drugs such as loratadine as prescribed by your doctor, apply tacrolimus and lidocaine locally to relieve itching, and apply glucocorticoids such as dexamethasone if necessary. Girls whose itching cannot be controlled by conservative treatment may consider treatment with perianal injection or surgical destruction of subcutaneous nerve endings around the anus to relieve itching.