Recently, we always encounter patients who are EBV-positive in our outpatient clinics to ask if it is nasopharyngeal carcinoma. Most of them have already undergone many tests in outside hospitals and basically ruled out the possibility of nasopharyngeal carcinoma, but they are still worried about whether they have missed the diagnosis. When it comes to EBV positivity, there is a little bit of a feeling of fear, but in fact it is not that terrible. One thing we have to admit is that the incidence of nasopharyngeal cancer is indeed higher in those who are positive for EBV antibodies than in those who are negative. Let’s take an analogy, we all know that smoking is easy to get lung cancer, so let’s compare EBV positive to smoking and nasopharyngeal cancer to lung cancer, isn’t it better to understand this problem? Similarly, many EB-positive patients do not get nasopharyngeal cancer. Guangdong Province is a region with a high incidence of nasopharyngeal cancer. The EB virus and nasopharyngeal cancer are closely related, and the rate of positive EB virus antibodies in Guangdong is 5-10%, and the detection rate of nasopharyngeal cancer is 253/100,000. EBV positive basically means that there is a viral infection, but I have to say that one situation is false positive, mainly because the test is not accurate enough now, in addition to the cold, long-term fatigue and discomfort or transient elevation are the causes of EB positive. It is only an indication of an existing EBV infection. However, if the blood test is positive for immunoglobulin EA (lgA), it is important to be alert. In particular, there is a difference between a “positive antibody” and a “high or low titer”. Clinically, a high titer is more likely to develop into nasopharyngeal cancer than a low titer. According to the data, patients with continuous increase in positive titers for several years, such as from 1:5 positive to 1:80 positive or 1:10 positive to 1:360 positive, 18.5% develop nasopharyngeal carcinoma within three years and 33.3% develop nasopharyngeal carcinoma within five years. Therefore, those with consistently positive antibody titers are “high risk” and should be of particular concern. What should I do if I find out that I am positive for EBV? I think this is the most important concern. First, check if you have any of the following symptoms: tinnitus, stuffy ears, hearing loss, headache (unilateral), dizziness, facial numbness, changes in vision, diplopia, neck lumps, etc. If necessary, go to an ENT specialist for an examination. If there are no above symptoms, you can also go to the hospital to check the nasopharynx, no problem can be rechecked once every 3 months to half a year, according to the EB titration changes we can roughly determine how a situation. Generally, we should not worry too much, but if we are not sure, we can go to the hospital for examination. In addition, we would like to emphasize a problem of nasopharyngeal cancer: family aggregation phenomenon, after the risk group with family history, the following symptoms should be paid attention to: EBV positive, titer continues to rise, persistent nasal congestion, nosebleed, hearing loss, tinnitus, headache, facial numbness, diplopia, swollen lymph nodes in the neck. If you are over 40 years old, have long-term smoking and drinking, and have symptoms of enlarged lymph nodes in the neck with progressive enlargement, painlessness and hard texture, you should go to hospital for examination in time for early diagnosis and treatment.