1, mental factors: mental trauma, excessive fatigue, anxiety and sadness, restlessness, sleepless nights. The biochemical pathway of tyrosine, mental stress, sympathetic excitement, increased synthesis of catecholamines, constitutes a competitive inhibition of melanin synthesis. Psychological stress can affect the interaction between the central nervous system and the immune system, causing immune disorders.
2, diet: excessive drinking and eating seafood, triggering immune disorders, endocrine function, affecting the absorption of zinc.
3, physical factors: sunlight: excessive sun exposure leads to hyperfunction of melanocytes, prompting their loss and causing early decline, excessive melanin production, accumulation of intermediate products, resulting in damage or death of melanocytes. Trauma and surgery: damage melanocytes and induce immune disorders. Mechanical stimulation: friction, pressure, scratching.
Chemical factors: phenolic compounds, rubber gloves, cleaning agents, plastic toys; 5, inflammatory factors: bacteria, viruses and fungi, release of antigens, triggering immune response, damage to melanocytes; 6, season: spring is high, summer is second, autumn is third, winter is the lowest, late spring and early summer and UV-related, early spring and diet, work and rest, emotional related.
7, age: adolescents and mental factors and immune disorders, adolescence, before and after pregnancy or childbirth, menopause and neuroendocrine related.
8, irregular work and rest: biological clock disorders, neuroendocrine disorders.