A fine yellow verrucous rash is commonly seen in acute neurologic Niemann-Pick disease, also known as sphingomyelin deposition disease, which is a congenital disorder of glycolipid metabolism. It is characterized by an all-mononuclear macrophage and a large number of foamy cells in the nervous system containing neurosphingolipids. So how to prevent fine yellow verrucous rash? There is no special treatment, mainly symptomatic treatment, attached to lipid diet, strengthen nutrition. 1, antioxidants vitamin C, E or butylated styrene, can stop the peroxidation of unsaturated fatty acids contained in the nerve sphingolipids M and poly and reduce the formation of lipofuscin and free radicals. 2.Splenectomy is suitable for non-neurological type with hypersplenism. 3.Embryonic liver transplantation has been reported to be successful.