It is generally possible not to take medication after total excision of lobular carcinoma in situ of breast. However, the specific situation depends on the patient’s postoperative condition. It is recommended that the patient should take professional postoperative conditioning under the doctor’s advice according to the pathological condition. Because carcinoma in situ is the earliest stage of breast cancer, the cancer cells are confined in the epithelial layer without breaking through the basement membrane, and there is no chance for spreading and metastasis to the blood vessels, lymphatic vessels, or tissues in the deeper layer of basement membrane. These patients can achieve a better prognosis through surgical resection. Usually, lobular carcinoma in situ does not require chemotherapy like invasive carcinoma, but radiotherapy is needed if the carcinoma in situ has a tendency to become more frequent. If estrogen receptor is positive, endocrine therapy can be used to reduce recurrence and metastasis. In daily life, patients should keep good mood, do not have too much psychological pressure, avoid taking too much spicy and stimulating food, and take light diet. If you feel unwell, you should consult a doctor in time and cooperate with him/her for active treatment. The postoperative treatment program is recommended to follow the advice of the clinician.