The mechanism of intracranial aneurysm occurrence and development is currently believed to be composed of various factors including genes, environment as well as anatomy, among which hemodynamic factors have taken a dominant role in the formation of intracranial aneurysms. Studying and analyzing the vascular geometrical structure and the generation and development of intracranial aneurysms is one of the hotspots of current research. In order to clarify the relationship between geometric morphometric parameters based on vascular imaging and the occurrence and development of basilar apical artery aneurysms (BTAs), Anil Can et al. from Brigham and Women’s Hospital, Harvard Medical School, Boston, USA, utilized univariate and multivariate statistical analyses to analyze the relationship between geometric morphometric parameters of blood vessels and BTAs, and the results were published in the 76th issue of 2015 of the Neurosurgery journal. They collected CT angiography (CTA) images of 66 patients (33 BTAs and 33 other aneurysms) from 2008 to 2013, and measured the 3D model of the aneurysm and the geometrical and morphological parameters of the surrounding vessels (including the diameter of the vessel, the angle between the vessel and the vessel, etc.) using 3D-Slicer software. On the basis of correction for other morphological parameters and clinical variables, multiple regression analysis showed that an increase in the angle between the posterior cerebral arteries on both sides (OR=1.04; P=1.42×10-3) as well as a decrease in the diameter of the basilar arteries (OR=0.23; P=0.02) were both strongly associated with the formation of BTAs. Clinical data statistics showed that there was no statistically significant difference in risk factors affecting the development of aneurysms, including patients’ age, gender, history of hypertension, and history of smoking, between the basilar aneurysm group and the non-basilar aneurysm group, while patients’ family history was significantly higher in the BTA group than in the non-BTA group, and the difference between these two groups was statistically significant (P=0.01) (Table 1). The difference in the diameter of the basilar artery and the diameter of the P1 segment of the posterior cerebral artery was not statistically significant between the two groups, whereas the difference in the P1-P1 angle of the posterior cerebral artery was statistically significant (P=1.31×10-5). Univariate analysis showed that basilar artery aneurysm formation was associated with smaller basilar artery diameters and greater differences between the diameters of the P1 segment of the posterior cerebral artery, but the differences in these correlations were not statistically significant. Multivariate analysis showed that smaller basilar artery diameters with larger P1-P1 angles were strongly associated with basilar artery aneurysm formation (Table 3). This study reinforces that changes in the anatomic characteristics of peripheral vessels have an important role in the hemodynamics of aneurysm formation, and that these simple 3D-reconstruction measurements provide an easy and rapid method for aneurysm screening and risk assessment in high-risk patients. The causes of intracranial aneurysm formation are a combination of heredity, poor lifestyle habits, and vascular anatomy, morphology, and structure. Hemodynamic changes in vascular wall structure and anatomical morphology play an important role in the formation of aneurysms. In this article, the authors found that smaller basilar artery diameter and larger angle between bilateral posterior cerebral arteries were closely related to the formation of aneurysms at the apex of the basilar artery by measuring the diameter of the basilar artery and the angle between bilateral posterior cerebral arteries on CTA images. Thus, it is considered a simple and quick method to identify patients at high risk of basilar artery aneurysm and risk assessment. The present article is a retrospective study, and the data were measured in patients who had already developed an aneurysm of the apex of the basilar artery. In the high-risk group without basilar aneurysm, even if there is a small diameter of the lumen of the basilar artery and a large angle of pinch between the posterior cerebral arteries on both sides of the brain, it is still unknown whether or when basilar aneurysms form, and the number of millimeters of diameter of the basilar artery and the number of degrees of the pinch angle between the posterior cerebral arteries are greater than the number of millimeters of diameter. There are no clear criteria for aneurysm formation. Therefore, it is of little significance as a guide in actual clinical practice. Only through rigorous RCT studies, firstly, it is necessary to determine the population standard of basilar artery diameter and the angle between bilateral posterior cerebral arteries; secondly, it is necessary to determine the incidence of basilar artery aneurysm in high-risk groups; thirdly, it is necessary to find out whether there are basilar artery diameters lower than the standard and the angle between bilateral posterior cerebral arteries greater than the standard in patients with basilar artery aneurysm in high-risk groups, and then to formulate a standard to guide the clinical practice. Clinical practice. Cerebrovascular disease has become the second most dangerous disease for human health, and with environmental factors and poor lifestyle habits, as well as early ageing, we will be faced with an increasing number of patients with intracranial aneurysms. With the continuous improvement of CT as well as MRI technology and the improvement of image clarity, more and more high-risk patients will be detected earlier. This article gives us good inspiration for the study. By studying CTA or MRA images, it is possible to detect morphological changes in cerebral blood vessels, alterations in the vessel wall, and to understand the pattern of intracranial aneurysms and the role that hemodynamics plays in aneurysm formation, so as to achieve better prevention of intracranial aneurysms and to reduce the social hazards caused by intracranial aneurysms.