Cold urticaria is generally divided into hereditary and acquired, hereditary is less common clinically, acquired is a common clinical type, usually in contact with cold wind, cold water and other triggers, resulting in the body wind mass, treatment is specifically as follows: 1, the first choice of antihistamines, such as antihistamines cetirizine, loratadine, fexofenadine and other treatment, can also choose to have a sedative effect of antihistamines, such as paracetamol, ketotifen. In addition, the tricyclic antidepressant Doxepin also has a therapeutic effect on some patients; 2. In addition to medication, attention should be paid to avoid triggering factors, i.e., pay attention to keeping warm and avoiding cold in exposed areas; 3. When the effect of using the above drugs is not good, it is also important to think that cold urticaria may be one of the manifestations of certain diseases, such as paroxysmal sleep hemoglobinuria and cryoglobulinemia, etc. A comprehensive examination should be conducted to avoid delaying The patient’s condition.