The treatment of diabetic painful neuropathy is divided into: medication for the pathogenesis of neuropathy and medication for the pain symptoms, commonly used drugs include α-lipoic acid, methylcobalamin and pregabalin. 1. Drug treatment for pathogenesis includes anti-oxidative stress drugs (representative drug is α-lipoic acid), aldose reductase inhibitors, nutritive drugs (methylcobalamin, etc.), and drugs to improve microcirculation (pancreatic kininogenase, prostaglandin). 2. Pharmacological treatments for pain symptoms include tricyclic antidepressants (amitriptyline, promethazine), anticonvulsants (gabapentin, pregabalin) and so on. The above medications are available for the treatment of diabetic painful neuropathy and should be purchased and used under the guidance of a medical professional.