There are several aspects to consider when sleeping with shortness of breath. First, whether there is allergic rhinitis, allergic asthma in the respiratory system, due to the vagus nerve excitation at night when sleeping, causing the contraction of the bronchi resulting in the inhalation of gas feels insufficient, the need to take deep breaths and cause the phenomenon of shortness of breath. Second, in the case of elderly people with previous diabetes, hypertension, coronary heart disease, myocardial ischemia, myocardial infarction and other similar conditions, shortness of breath caused by slow blood flow is likely to occur at night. Thirdly, we should also be alert to digestive system diseases, such as gastroesophageal reflux disease. When such patients are lying down at night, gastric acid tends to move up the esophagus through the cardia, leading to the patient’s symptoms of chest tightness and shortness of breath. These three conditions occur and need to be treated accordingly according to different diseases. In the case of respiratory conditions, anti-inflammatory and anti-allergic medications should be given, and glucocorticoids should be inhaled if necessary. Cardiovascular problems can be given quick-acting heart pills and isosorbide mononitrate extended-release tablets orally to dilate heart vessels and improve blood supply. For the digestive system, proton pump inhibitors and pro-gastrointestinal motility drugs, such as morpholine, mosapride, omeprazole, rabeprazole, pantoprazole, etc., should be given to relieve the symptoms of chest tightness and shortness of breath as soon as possible.