The clinical manifestation of shortness of breath and inability to breathe when walking may be caused by respiratory-related diseases or cardiovascular-related diseases. Respiratory-related diseases include chronic obstructive pulmonary disease, tuberculosis, lung tumor, interstitial fibrosis, etc. Cardiovascular-related diseases are mainly due to various heart diseases that cause cardiac insufficiency, such as coronary heart disease, rheumatic heart disease, dilated cardiomyopathy and other cardiac insufficiency. When patients have shortness of breath after activity, they need to actively seek medical attention, improve relevant examinations, clarify the diagnosis, and take appropriate treatment according to the diagnosis. If the patient has shortness of breath after activity due to cardiac insufficiency, cardiac strengthening, diuretic and vasodilator treatment should be given according to the condition. If the patient has shortness of breath due to chronic obstructive pulmonary disease, inhalation of bronchodilators, oral aminophylline, etc. may be used.