The application of 3D CT navigation system for precise positioning in maxillofacial surgery has achieved good results: 3D CT navigation system has been widely used in neurosurgery to precisely guide the surgical approach and clarify the target location intraoperatively. It can help the operator to perform surgery without direct vision, effectively reducing complications and surgical risks. Director Zhang Hai Zhong has successfully applied this high technology in oral and maxillofacial surgery to treat certain difficult and complex diseases, which is now mainly used in the treatment of foreign body retention in the maxillofacial neck, maxillofacial skull base tumors, complex fractures in the maxillofacial area, trigeminal neuralgia, etc. Good results have been achieved, and his technology and experience have been exchanged in academic conferences at home and abroad for many times, and have been unanimously praised by experts and scholars at home and abroad. The “frameless stereotactic navigation system”, that is, the three-dimensional CT navigation system, which is based on powerful computer technology and three-dimensional image processing software as the core, using satellite positioning theory, through infrared remote sensing technology, can accurately locate the location of the patient’s lesion during surgery, determine the boundary of the lesion and the relationship with the surrounding tissue structure, for The surgeon can design one or more optimal surgical approaches from the incision to the lesion at the closest distance, avoiding important nerve tissues, and can continuously verify the accuracy of the surgical approach. This technique allows for smaller incisions, less bleeding, fewer complications, and removal of the lesion with minimal damage and millimeter-level accuracy, resulting in a significantly improved prognosis, a significant reduction in the number of hospital days, and a significant improvement in the quality of patient survival. Trigeminal neuralgia is mainly manifested as a sudden onset of extremely severe pain in a branch of the trigeminal nerve. Nowadays, a more advanced approach is to perform radiofrequency temperature control treatment on the trigeminal nerve at the base of the skull, but the difficulty lies in the complex structure of the skull base, the proximity to the surrounding important neurovascular and the different local anatomical structures of the patients, and many complications will occur only based on the experience of clinicians. Stereotactic technique can effectively improve the accuracy of round hole and oval hole puncture, and has great advantages in the treatment of trigeminal neuralgia. For cases of metallic foreign bodies in the head and neck, intraoperative combination of 3D CT navigation system can accurately and quickly locate and remove foreign bodies with 100% success rate. The 3D CT-guided radioactive particle implantation can precisely implant the particles in the lesion location, while reducing the surgical trauma to a minimum and reducing the patient’s surgical pain without affecting the treatment effect. It is ideal for patients who are too weak to undergo surgery, patients with recurrent tumors but cannot tolerate surgery due to objective factors such as chemotherapy, and patients who are unwilling to undergo surgery. The neuronavigation has the advantages of thorough surgical planning, high treatment precision, low trauma, effective avoidance of complications, and avoiding excessive exposure of the operator and patient to X-rays, etc. It has a good application prospect in oral and maxillofacial surgery.