Diabetic peripheral neuropathy can be treated by controlling blood glucose, nutritive nerves, improving microcirculation, etc. It is recommended to follow the doctor’s instructions to take medication. 1. Control blood sugar: peripheral neuropathy is a chronic complication of diabetes mellitus, and the first step in treating peripheral neuropathy is to control blood sugar. Patients should take glucose-lowering drugs, such as metformin and glibenclamide, as prescribed by the doctor. Diabetic patients with poor drug control can also control blood sugar by subcutaneous injection of insulin, adjusting the diet structure and other methods. 2 Nutritional nerve: commonly used drugs are methylcobalamin, nerve growth factor and so on. To achieve the purpose of improving the microcirculation around the diabetic nerve and nourishing the nerve. 3. Improve microcirculation: Reduced blood flow to peripheral nerves is an important factor leading to the occurrence of diabetic neuropathy. By dilating blood vessels, improving blood hypercoagulability and microcirculation, and improving blood and oxygen supply to nerve cells, the clinical symptoms of diabetic neuropathy can be effectively improved. Commonly used drugs are prostaglandin E, be prostaglandin sodium, cilostazol and so on. Diabetic peripheral neuropathy requires long-term comprehensive treatment, and it is recommended that patients seek timely medical treatment and follow the doctor’s instructions for professional comprehensive treatment.