Drugs such as ibuprofen are commonly used to reduce fever and it is usually recommended to take it once in 4-6 hours and not more than 4 times in 24 hours. Ibuprofen is a non-steroidal anti-inflammatory drug with antipyretic and analgesic effects, and should be taken under the guidance of a professional doctor as much as possible. When a patient has a fever of 38.5℃ or more, he can use ibuprofen in appropriate amounts to reduce fever after excluding contraindications to the use of the drug. If the fever continues to persist after the use of antipyretic drugs, it is recommended to take another dose at an interval of 4-6 hours, but not more than 4 times in 24 hours. Because of excessive application of ibuprofen, gastrointestinal adverse reactions, such as gastric ulcer and gastric perforation, may occur. In addition, taking antipyretic drugs can be combined with physical cooling to enhance the effect of fever reduction. Concurrent use of other non-steroidal anti-inflammatory and analgesic drugs such as naproxen, acetaminophen, diclofenac sodium, etc. is not recommended during the use of ibuprofen. During the period of taking ibuprofen to reduce fever, pay attention to drink more warm water to prevent dehydration.