Recent medical research has found that 10% to 30% of infertility is due to drugs. The main drugs that may cause male infertility are the following ten categories: ① anti-ulcer drugs such as metformin and Tegretol, which can inhibit male and female libido and can cause male and female frigidity and male impotence. ② Many sleeping pills can inhibit libido, or even loss of libido, and can reduce testosterone production in men, penile erection difficulties, non-ejaculation, as well as female menstrual disorders or amenorrhea. ③Compound antihypertensive tablets, reserpine, methyldopa, guanethidine, insulin, colistin, buckling and other antihypertensive drugs can affect erectile function, cause decreased libido, impotence, non-ejaculation and menstrual disorders in women. ④Amitriptyline hydrochloride, promethazine and other antidepressants, have an effect on the libido of both men and women. ⑤ Cyclophosphamide, methotrexate, salazosulfapyridine, colchicine, etc. can cause decrease in semen, decrease in sperm motility, testicular atrophy, and absence of sperm. (6) Ampicillin, leucovorin, thyroid preparations, methiodiazine, etc. may cause decreased libido, menstrual irregularities, ovulation disorders and endocrine abnormalities, etc. Teldene, Librium, Atropine and Digitalis are commonly used to cause impotence. Commonly used tretinoin can cause degeneration of spermatogenic ducts in the testes. Prednisolone can cause decrease in sperm semen and menstrual disorders. Drugs containing female progesterone can cause loss of sexual desire. (7) Commonly used testosterone in men can cause testicular atrophy, lack of semen, and penile hypertrophy. (8) Fluphenazine hydrochloride diet pills can suppress libido while suppressing appetite. ⑨ Alcohol decreases the level of testosterone in the blood and can cause egg or sperm damage, malformation, reduction, stunting, and reduced motility. Long-term alcohol consumption can also cause impotence and non-ejaculation. Therefore, frequent use of medicinal alcohol can also cause infertility. These toxic substances can act on the male reproductive system and directly invade the germ cells. They either kill immature sperm or make them mutilated and destroy their genes. A man’s germ cells, at all stages from spermatogenesis to development and maturation into sperm, are extremely vulnerable. When the damaged sperm barely unites with the egg, fetal development is impaired, and miscarriage and fetal death are inevitable. Even if the damage to the sperm is minor and the baby survives, the health of the child can be a source of anxiety and discomfort for the parents. Among men who are exposed to a lot of toxic substances, it is not difficult to find that their children are prone to neurological deformities, congenital heart disease, digestive system deformities, leukemia, brain tumors and other diseases, the incidence of which is significantly higher than that of the general population.