Modern medicine is increasingly developed, the application of drugs is very common, drugs in the treatment of disease at the same time will also produce some adverse should. According to clinical observations, there are many drugs that have adverse effects on sperm production and men’s sexual function. The extent of the effect depends on a variety of factors, such as the dose of the drug, the length of time to take the drug, and so on. The sensitivity of the individual is also an important reason. Currently, according to clinical research, the following types of drugs have a greater impact on male fertility. 1, chemical drugs for the treatment of tumors: clinical observations confirm that the vast majority of chemotherapy drugs have side effects that lead to male infertility. Such as cyclophosphamide, the drug can destroy the spermatogenic cells of the testis, so that the testis spermatogenic function decreases, if the drug in adolescence or puberty can cause testicular atrophy; 2, anti-hypertensive drugs: the main side effect of this class of drugs to reduce the patient’s libido, can lead to ejaculation difficulties, or even no ejaculation. Such as methyldopa, quazepam can cause impotence and difficulty in ejaculation; 3, sedatives: after the application of barbiturates, there is a decrease in libido, impotence, etc.; 4, narcotics: from the study of drug addicts found that: the use of opium or heroin can significantly inhibit sexual function, sperm production is also inhibited, there can also be delayed ejaculation or non-ejaculation, especially after taking heroin, the above phenomenon is more obvious; 5. Androgens and estrogens: In the treatment of many male diseases, androgens are widely used, but long-term, excessive application of androgens will inhibit the hypothalamic-pituitary-testicular axis and reduce sperm production, leading to infertility. In addition, in the application of estrogen therapy, such as long-term application of large amounts of male libido can also be rapidly fading, and eventually impotence and affect fertility; 6, anti-gastric acid drugs: the most commonly used are metformin (trade name Tegretol), ranitidine, etc.; 7, Chinese medicine: Lei Gong Vine, camphor, musk, etc.