Itchy symptoms and small blisters on bilateral calves may be related to contact dermatitis, acute eczema and other diseases. 1. Contact dermatitis is an allergic reaction that occurs when the skin comes into contact with irritating substances, which can be manifested in the clinic as localized redness, pimples, blisters, or even vesicles, and can be accompanied by varying degrees of itching. The most common irritants may be sewage, chemicals and so on. 2. Acute eczema is an inflammatory skin disease, but also related to allergies, with a variety of internal and external factors related to stimulation, in the clinical manifestations of more diverse forms, such as papules, pimples, blisters, vesicles, ulcers, etc., and will be accompanied by intense itching. Due to the large changes in the condition, the specific circumstances need to ask the doctor for an interview, it is recommended that patients with bilateral calf itching with small blisters to the hospital in time to find out the cause of the problem, and follow the doctor’s instructions for treatment.