Nephrotic syndrome (NS) can be caused by a variety of etiologies and is characterized by a group of clinical syndromes with increased glomerular basement membrane permeability, manifested by massive proteinuria, hypoproteinemia, high edema, and hyperlipidemia. 1. Wrong diagnosis. Some secondary nephropathies such as amyloid nephropathy, diabetic nephropathy and special renal diseases such as lipoprotein nephropathy and fibrous glomerulopathy are mistakenly treated as primary nephrotic syndrome by applying “hormone”, which of course cannot achieve satisfactory results. Or some secondary nephropathies that require different treatment plans, such as hepatitis C virus-induced cryoglobulin nephropathy and type V (membrane type) lupus nephritis, are also difficult to obtain satisfactory results when treated with one drug “hormone” alone. 2. Irregular treatment leads to frequent relapse of nephrotic syndrome. The main drug used in the treatment of nephrotic syndrome is “hormone”, and the general treatment principle of this drug is “adequate amount, slow reduction and proper maintenance”. Take prednisone as an example, the starting dose is 1mg/kg/d (40~60mg/d) taken in the morning for 8~12 weeks; in effective cases, the original dosage can be reduced by 10%~20% every 2~3 weeks, and then reduced to 10~15mg/d for appropriate maintenance treatment, for a total duration of 6 months~1 year. The initial amount is sufficient to help the disease remission, and the slow reduction and proper maintenance can prevent the disease recurrence. However, in clinical practice, for various reasons, some patients may have received irregular treatment such as insufficient dose of “hormone” and too fast reduction of dose, so that the nephrotic syndrome which should be the effective type of “hormone” becomes the frequent recurrence type of nephrotic syndrome. 3.Improper use of “hormone” affects the efficacy of “hormone”. Improper use of hormones affects the absorption, bioavailability and excretion of hormones, thus affecting the effectiveness of hormones. (1) For patients with severe nephrotic syndrome with severe clinical swelling, oral prednisone is used, which may affect the absorption of the drug due to severe edema in the gastrointestinal mucosa. (2) Prednisone should be administered to patients with poor hepatic function. Since prednisone needs to be converted to prednisolone by the liver in the body, this conversion function may be impaired when the liver is not functioning well, which may affect the bioavailability of the drug. (3) Ignore the interaction between drugs. We all know that patients with nephrotic syndrome often combine multiple complications and need to use several drugs at the same time. However, some drugs, such as carbamazepine and rifampin, can increase the excretion rate of prednisolone in the body by 60% and 143%, respectively, thus reducing the blood concentration of prednisolone. At this time, if the doctor ignores the interaction between these drugs, the therapeutic effect of the “hormone” can be affected. 4. The presence of comorbidities affects the therapeutic effect.