The treatment of lung adenocarcinoma with chest tightness and shortness of breath includes conservative treatment and surgical treatment. 1. Conservative treatment (1) General treatment: rest and oxygen inhalation, when there is chest tightness and shortness of breath, it is necessary to take rest in time to reduce the consumption of oxygen, and continuous low-flow oxygen inhalation should be carried out under the guidance of doctor to relieve the symptoms of chest tightness and shortness of breath when necessary. (2) Local treatment: when lung adenocarcinoma infiltrates local tissues, pleural effusion and pericardial effusion will occur, which will lead to chest tightness and shortness of breath, and local extraction of pleural effusion can alleviate the symptoms of chest tightness and shortness of breath; medication can be taken under doctor’s guidance such as bronchodilator and nebulizer inhalation drugs, drugs inhibiting the growth and metastasis of tumor cells, targeting drugs, immunotherapeutic drugs and so on. 2. Surgery: It is the main method to relieve chest tightness and shortness of breath in lung adenocarcinoma. Tumor and lesion tissue can be removed, and with radiotherapy to reduce the impact of lung cancer on lung tissue. It can promote the recovery of lung function. So that chest tightness and shortness of breath can be effectively relieved. If the chest tightness and shortness of breath cannot be relieved after resting, timely hospitalization is needed to prevent the condition from deteriorating.