Most of the breast swelling and pain is caused by breast enlargement, which includes common lobular enlargement, most commonly seen a week or so before menstruation, which causes breast swelling and pain; a small number of breast swelling and pain is due to cystic breast enlargement with many small blisters in the breast, which can be treated with prolotherapy pills, which are effective if the swelling and pain is relieved, but must be taken under the guidance of a doctor.