1, to take seriously the premarital medical examination, through the examination of some diseases found, such as hepatitis B, venereal disease, etc., these diseases are will affect the health of the offspring, triggering fetal malformations, only after the cure can be pregnant. 2, make good preparations before pregnancy, do not blindly pregnant, to be prepared, planned pregnancy, to carry out some necessary tests, such as rubella virus test. Rubella virus infection can lead to congenital heart disease and congenital deafness in the fetus, which can be prevented by rubella vaccination; folic acid tablets can be taken in the first trimester of pregnancy to prevent malformation of the fetal neural tube. 3, avoid pregnancy in spring and winter, spring and winter viruses are more, the incidence of fetal malformations in spring and winter pregnancy is significantly higher than in summer and autumn. 4.Establish perinatal health care card immediately after pregnancy, regular checkups, Down’s syndrome screening at 14-20 weeks, ultrasound test before 28 weeks, etc. These tests can find out whether the fetus is malformed in early pregnancy. 5, to prevent infectious diseases of the reproductive tract. The main cause of reproductive tract infectious diseases is unclean sexual behavior, so to regulate sexual behavior, has been diagnosed to timely treatment, pregnant women find their secretions have abnormal should also seek medical attention, not because of pregnancy and refuse to use drugs or even avoid medical treatment.