Patient: Description of the condition: Our little girl was born on April 27, 2006, weighing 1.928 kg, with a height of 42 cm and a head circumference of 32 cm, a full-term small sample. She has a precordial (complete endocardial cushion defect), which was operated at 3 months of age, and currently has a small amount of reflux. The main problem is slow growth. She now weighs 7.5 kg, is 78 cm tall, and has a head circumference of 42 cm. She has been examined in several hospitals and has been diagnosed with cerebral palsy, microcephaly, etc., but the diagnosis is not confirmed. Now she can walk alone but is unstable, can say two words briefly, gets angry easily and is easily frightened. Her mobility, intelligence, and language are clearly lagging behind. She had a brain CT at a month or so, which showed a brain mass density of 23 Hu. She started rehabilitation last year, which had some effect, and had 3 courses of rat nerve growth factor injections. Some doctors suspect a chromosomal problem, can the expert help confirm the diagnosis? Specialist: If you suspect a chromosomal problem, you can have a blood test for chromosomes. Patient: Dr. Yao, my daughter just had a chromosome test and no abnormality was found, can you please help diagnose what is wrong with her? Thank you so much! Specialist: Cerebral palsy and microcephaly can be diagnosed. There may have been an intrauterine infection and genetic metabolic disease cannot be ruled out (despite normal chromosomal testing). Blood and urine tandem mass spectrometry, EBV and CMV virus tests are recommended.