The main cause of chronic bacterial prostatitis is pathogenic infection, mainly retrograde infection, the pathogen is mainly Staphylococcus spp, often with a history of repeated episodes of urinary tract infection or persistent presence of pathogenic bacteria in the prostate massage fluid. The naming of chronic prostatitis belongs to the old classification system, in which prostatitis is divided into: acute bacterial prostatitis, chronic bacterial prostatitis, chronic non-bacterial prostatitis, prostate pain . The chronic prostatitis is divided into: chronic bacterial prostatitis and chronic non-bacterial prostatitis, both of which are equivalent to the NIH typing of prostatitis with type II and type III respectively. The reason and pathogenesis chronic bacterial prostatitis pathogenic factors are also mainly pathogenic infection, but the body resistance or/and pathogen virulence is weak, to retrograde infection, the pathogens are mainly Staphylococcus spp, followed by Escherichia coli, rod-shaped bacillus spp and enterococcus spp, etc. Prostate stones and urinary reflux may be important reasons for the persistence of pathogens and recurrence of infection. Chronic nonbacterial prostatitis has an unknown pathogenesis and a complex etiology that is widely debated: it may be caused by a single initiating factor, or it may be multifactorial from the beginning, with one or more of them playing a key role and interacting with each other; it may be a number of different diseases that are difficult to identify but have the same or similar clinical manifestations; or even these diseases may have been cured and the damage and pathology caused by them continue to act independently. Even if these diseases have been cured, the damage and pathological changes caused by it still continue to act independently. Most scholars believe that the main etiology may be a combination of pathogenic infection, inflammation, and abnormal pelvic floor neuromuscular activity and immune abnormalities. 1. Pathogenic infections. Although routine bacterial examination failed to isolate pathogens in patients with this type, they may still be associated with some specific pathogens: such as anaerobic bacteria, L-type Aspergillus, nanobacteria, or Chlamydia trachomatis, mycoplasma, etc. infections. Some studies have shown that the local prokaryotic DNA detection rate for this type of patient can be as high as 77%; some clinical “aseptic” prostatitis, which is predominantly chronic inflammation, recurrent or aggravated, may be associated with these pathogens. The other pathogens such as parasites, fungi, viruses, trichomonas, and Mycobacterium tuberculosis may also be important causative factors for this type, but there is a lack of reliable evidence and there is no unified opinion yet. 2. Urinary dysfunction. Many patients with prostatitis have a variety of urodynamic changes, such as reduced urinary flow rate, functional urinary tract obstruction, and dysfunction of the detrusor-urethral sphincter synergy. These functional abnormalities may only be a clinical phenomenon, and their nature may be related to various underlying pathogenic factors. 3. Psychosomatic factors. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. These changes in mental and psychological factors can cause plant nerve dysfunction, resulting in posterior urethral neuromuscular dysfunction, leading to pain in the pelvic region and dysfunctional urination; or cause changes in the function of the hypothalamic-pituitary-gonadal axis and affect sexual function, further aggravating the symptoms, and eliminating mental tension can lead to symptom relief or healing. However, it is not clear whether the psychosomatic changes are the direct cause or secondary manifestations. 4, neuroendocrine factors. Patients with prostate pain are often prone to fluctuations in heart rate and blood pressure, indicating that they may be related to autonomic responses. Their pain has the characteristics of visceral organ pain. Local pathological stimulation of the prostate and urethra triggers spinal reflexes through the afferent nerves of the prostate, activates astrocytes in the lumbar and sacral medulla, nerve impulses send out impulses through the genitofemoral nerve and the ilioinguinal nerve, and sympathetic nerve endings release norepinephrine, prostaglandins, calcitonin gene-related peptides, substance P, etc., causing vesicourethral dysfunction, and This leads to abnormal activity of the perineum and pelvic floor muscles and persistent pain and involvement pain in the corresponding areas other than the prostate. 5. Abnormal immune response. Recent studies have shown that immune factors play a very important role in the development and evolution of type III prostatitis. Changes in the levels of certain cytokines, such as IL-2, IL-6, IL-8, IL-10, TNF-α and MCP-1, can occur in the prostatic fluid and/or seminal plasma and/or tissues and/or blood of patients, and IL-10 levels are associated with type III The level of IL-10 is positively correlated with the pain symptoms of patients with prostatitis III, and the application of immunosuppressive therapy has a certain effect. 6, the theory of oxidative stress. Under normal circumstances, the body’s oxygen radical production, utilization and removal in a dynamic balance. Prostatitis patients with excess oxygen radical production or / and the role of the free radical scavenging system is relatively reduced, thus reducing the body’s ability to respond to oxidative stress, oxidative stress products or / and by-products increase, may also be one of the pathogenesis. 7, pelvic related disease factors. The actual fact that some prostatitis patients often have dilated prostate peripheral plexus, hemorrhoids, varicose veins, etc., suggests that some chronic prostatitis patients’ symptoms may be related to pelvic venous congestion and blood stagnation, which may also be one of the reasons for the long-lasting treatment.