Typically, varicella vaccine refers to the live attenuated varicella vaccine, which is made from the internationally accepted attenuated strain of varicella virus OKa, cultured in MRC-5 human diploid cells and, less commonly, inactivated varicella vaccine. Varicella vaccine stimulates the body to develop immunity against varicella virus and is used to prevent varicella and diseases caused by varicella-zoster virus infection. Chickenpox is caused by the varicella-zoster virus, which is highly infectious and the only host for humans. Patients usually present with symptoms such as pemphigus, papules, fever, and loss of appetite after infection. Since there is no specific medicine for chickenpox, varicella vaccination is the only effective means to prevent chickenpox, so it is recommended that adults and adolescents who have not had chickenpox actively receive the varicella vaccine. The susceptible population for varicella is mainly healthy children between 12 months and 12 years of age, and it is clinically recommended to start vaccination when children are 2 years old. The success rate of varicella immunization is high, with a seropositivity rate of >98% after 6 weeks of varicella vaccination, and the immunization effect lasts for a long time, reaching about 10 years. Adverse reactions after varicella vaccination are rare, and some patients may occasionally see low fever and mild rash after vaccination, which may disappear on their own for milder symptoms. Therefore, it is recommended to observe the changes of vital signs after vaccination, and pay attention to rest, light diet, and abstain from spicy, stimulating and cold foods, such as chili and garlic, for good preventive care.