How to select drugs and regimens for adjuvant chemotherapy Based on the available evidence of evidence-based medicine, the selection of appropriate drugs and regimens is the most important aspect of standardized treatment, which relies on a thorough understanding of the effectiveness and safety of the various drugs/regimens available, especially the side effect profile. Efficacy of adjuvant chemotherapy in colon cancer The main drugs and regimens that have been validated in adjuvant chemotherapy for colon cancer are fluorouracil-based (intravenous/oral) monotherapy and combination regimens with oxaliplatin and irinotecan. Oral fluorouracil formulations From a pharmacoeconomic effect-cost perspective, oral fluorouracil formulations that maintain efficacy will overcome the inconveniences associated with 5-FU infusion and have a high pharmacoeconomic value. Two large global phase III trials have been conducted to evaluate the efficacy of these two agents in adjuvant chemotherapy for colon cancer in combination with chemotherapy. In recent years, oxaliplatin (Loxadine) and irinotecan (Kepitol) have achieved significant efficacy in the chemotherapy of advanced colon cancer and have had a profound impact on the treatment of colorectal cancer. impact on the treatment of colorectal cancer. Therefore, the possibility of using these two drugs in adjuvant chemotherapy became a natural idea.